Publications

Preprints

Marino ND, Talaie A*, Carion H*, Johnson M, Zhang Y, Silas S, Li Y, and Bondy-Denomy J. Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein. https://doi.org/10.1101/2022.11.29.518452

Research Articles

Marino ND*, Zhang JY*, Borges AL*, Sousa AA, Leon LM, Rauch BJ, Walton RT, Berry JD, Joung JK, Kleinstiver BP, Bondy-Denomy J. Discovery of widespread type I and type V CRISPR-Cas inhibitors. Science. 2018 Oct 12;362(6411):240-242. doi: 10.1126/science.aau5174. Epub 2018 Sep 6. PubMed PMID: 30190308; PubMed Central PMCID: PMC6520112.

Marino ND*, Pinilla-Redondo R*, Bondy-Denomy J. CRISPR-Cas12a targeting of ssDNA plays no detectable role in immunity. Nucleic Acids Res. 2022 Jun 24;50(11):6414-6422. doi: 10.1093/nar/gkac462. PubMed PMID: 35670674; PubMed Central PMCID: PMC9226536.

Pinilla-Redondo R, Shehreen S, Marino ND, Fagerlund RD, Brown CM, Sørensen SJ, Fineran PC, Bondy-Denomy J. Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements. Nat Commun. 2020 Nov 6;11(1):5652. doi: 10.1038/s41467-020-19415-3. PubMed PMID: 33159058; PubMed Central PMCID: PMC7648647.

Marino ND, Panas MW, Franco M, Theisen TC, Naor A, Rastogi S, et al. (2018) Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii. PLoS Pathog 14(1): e1006828. https://doi.org/10.1371/journal.ppat.1006828.

Marino ND and Boothroyd JC. Toxoplasma growth in vitro is dependent on exogenous tyrosine and is independent of AAH2 even in tyrosine-limiting conditions. Exp Parasitol. 2017; 176: 52-58.

Franco M*, Panas MW*, Marino ND*, Lee MC, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP, Pourmand N, Boothroyd JC. A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. mBio. 2016; 7(1):e02231-15. doi: 10.1128/mBio.02231-15.

Shastri AJ, Marino ND*, Franco M*, Lodoen MB, Boothroyd JC. GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response. Infect Immun. 2014 Jun;82(6):2595-605.

Coffey MJ, Sleebs BE, Uboldi AD, Garnham A, Franco M, Marino ND, Panas MW, Ferguson DJ, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA, Tonkin CJ. An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell. Elife. 2015; 4. pii: e10809. doi: 10.7554/eLife.10809.

Naor A, Panas MW, Marino N, Coffey MJ, Tonkin CJ, Boothroyd JC. MYR1-Dependent Effectors Are the Major Drivers of a Host Cell's Early Response to Toxoplasma, Including Counteracting MYR1-Independent Effects. mBio. 2018 Apr 3;9(2). doi: 10.1128/mBio.02401-17. PubMed PMID: 29615509; PubMed Central PMCID: PMC5885026.

*Equal contributors

Reviews

Marino ND, Brodsky IE. Immunology: NACHT domain proteins get a prokaryotic origin story. Curr Biol. 2023 Aug 21;33(16):R875-R878. doi: 10.1016/j.cub.2023.06.084.

Marino ND. Phage Against the Machine: Discovery and Mechanism of Type V Anti-CRISPRs. J Mol Biol. 2023 Apr 1;435(7):168054. doi: 10.1016/j.jmb.2023.168054. Epub 2023 Mar 18. Review. PubMed PMID: 36934807.

Marino ND, Pinilla-Redondo R, Csörgő B, Bondy-Denomy J. Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies. Nat Methods. 2020 May;17(5):471-479. doi: 10.1038/s41592-020-0771-6. Epub 2020 Mar 16. Review. PubMed PMID: 32203383; PubMed Central PMCID: PMC8510557.